Malignant Mesothelioma

Malignant mesothelioma is an uncommon, but no longer rare, cancer that is difficult to diagnose and poorly responsive to therapy. Malignant mesothelioma is the most serious of all asbestos-related diseases.
A layer of specialized cells called mesothelial cells lines the chest cavity, abdominal cavity, and the cavity around the heart. These cells also cover the outer surface of most internal organs. The tissue formed by these cells is called mesothelium.
The mesothelium helps protect the organs by producing a special lubricating fluid that allows organs to move around. For example, this fluid makes it easier for the lungs to move inside the chest during breathing. The mesothelium of the chest is called the pleura and the mesothelium of the abdomen is known as the peritoneum. The mesothelium of the pericardial cavity (the "sac-like" space around the heart) is called the pericardium.
Tumors of the mesothelium can be benign (noncancerous) or malignant (cancerous). A malignant tumor of the mesothelium is called a malignant mesothelioma. Because most mesothelial tumors are cancerous, malignant mesothelioma is often simply called mesothelioma.
Mesothelioma was recognized as a tumor of the pleura, peritoneum and pericardium in the late 1700's. However it was not until much later, in 1960, that this particular type of tumor was described in more detail and even more importantly, its association with asbestos exposure was recognized. The first report linking mesothelioma to asbestos exposure was written by J.C.Wagner, and described 32 cases of workers in the "Asbestos Hills" in South Africa. Since than the relationship between mesothelioma and asbestos exposure has been confirmed in studies around the world.
The incidence of mesothelioma in the United States remains very low, with 14 cases occurring per million people per year. Despite these numbers the noticed threefold increase in mesothelioma in males between 1970 and 1984, is directly associated with environmental and occupational exposure to asbestos, mostly in areas of asbestos product plants and shipbuilding facilities.
Although the disease is much more commonly seen in 60-year old men, it has been described in women and early childhood as well. The cause of the disease is not so well understood in these latter two groups, but there is some evidence of possible asbestos exposure for some of these cases as well.
Mesothelioma is one of the deadliest diseases known to man; the average life span of an inflicted person from the time of diagnosis until death is less than 24 months. It's a disease that strikes approximately 3,000 United States citizens each and every year; hard working people who have labored for a lifetime to provide for their families, doing the work that keeps this country running and a great place to live. They worked in factories, at shipyards, in mines, for the US military, as engineers, as pipefitters, as steel workers, as auto mechanics, and in so many other professions. They came home to their loved ones exhausted and covered in dirt and dust; tired, but content that they had a job and were providing for their family. Content that they were putting food on the table and a house over their loved one's heads. Content that they were working to make a better life for their families in this generation and the next...
But what they didn't know was that while they were working so hard, they were not only slowly killing themselves, but those that they were working so hard to help; their family, their loved ones.
What is the mesothelium?
The mesothelium is a membrane that covers and protects most of the internal organs of the body. It is composed of two layers of cells: One layer immediately surrounds the organ; the other forms a sac around it. The mesothelium produces a lubricating fluid that is released between these layers, allowing moving organs (such as the beating heart and the expanding and contracting lungs) to glide easily against adjacent structures.
The mesothelium has different names, depending on its location in the body. The peritoneum is the mesothelial tissue that covers most of the organs in the abdominal cavity. The pleura is the membrane that surrounds the lungs and lines the wall of the chest cavity. The pericardium covers and protects the heart. The mesothelial tissue surrounding the male internal reproductive organs is called the tunica vaginalis testis. The tunica serosa uteri covers the internal reproductive organs in women.
What Is My Diagnosis?
There are three types of mesothelioma. Pleural mesothelioma is a cancer of the lining of the lung (pleura), peritoneal mesothelioma is a cancer of the lining of the abdominal cavity (peritoneum), and pericardial mesothelioma is a cancer of the lining surrounding the heart (pericardium). Sub-types (or cell types) of mesothelioma are epithelioid (the most common, and considered the most amenable to treatment), sarcomatous (a much more aggressive form), and biphasic or mixed (a combination of both of the other cell types).
The structural appearance of cells under the microscope determine the cell or sub-type of mesothelioma. Epithelioid is the least aggressive; sarcomatoid, the most aggressive. The biphasic or mixed cell type shows structural elements of both of the other two.
There are three types of mesothelioma. Pleural mesothelioma is a cancer of the lining of the lung (pleura), peritoneal mesothelioma is a cancer of the lining of the abdominal cavity (peritoneum), and pericardial mesothelioma is a cancer of the lining surrounding the heart (pericardium). Sub-types (or cell types) of mesothelioma are epithelioid (the most common, and considered the most amenable to treatment), sarcomatous (a much more aggressive form), and biphasic or mixed (a combination of both of the other cell types).

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Cures for Lung Cancer - The Important Things That You Should Know

"I'm sorry to inform you that you have lung cancer and you only have 12 months to live."
If the doctor said this you, what should be the first thing you do? That's right. You would be running around, researching the internet, asking for prayers, looking everywhere to find a cure for lung cancer. Why? Because we have been told that there is no cure for this one and that it is basically a death sentence.
This article will not try to convince you that there are cures for lung cancer. We KNOW that there are; it's just a matter of you opening up your mind to a brand new perspective; a whole new worldview that maybe something is amiss here.
With all the technology we have in this day and with all the resources at our disposal to research cures for lung cancer, with billions of dollars spent on experiments and lab tests; can we at least be optimistic and think that maybe they did find a cure?
Now you ask me, if they did find the perfect cure, why would they keep it from the public?
The answer is really surprising: THE LOVE OF MONEY! The root of all evil!
Billions of dollars are spent by cancer patients each year on treatments and medication. If the medical industry announced that a miracle has happened and that they found cure for lung cancer, what would happen then? They would lose those billions of dollars.
Drug companies and private medical institutions know this so they conspire to keep this fact away from the public. Instead of giving the cure, which would then stop the patient from coming back to spend more, they would treat the disease as slowly as possible so they keep coming back.
To be honest with ourselves, if we found out that there really are cures for lung cancer, would you still believe the way of the "accepted" and traditional methods like chemotherapy or surgery or high-energy radiation? I think most assuredly not. But this doesn't take away the fact that there are cures for lung cancer. And they are found in alternative medicine.
There are lots of alternative medicine that can be found not only through internet research but even contemporary physicians have begun to accept the healing powers of methods like Controlled Amino Acid Therapy (CAAT), Photodynamic Therapy or PDT, and many others.
If you do research and then dig deeper, you will find dozens of testimonies from people who have found a cure using the alternative methods. Just be under the impression that cancer is a symptom and not the disease itself. If you change the lifestyle, you can find cures for lung cancer; although the medical institutions would strongly disagree with you.

For effective cures for lung cancer and for more prevention and treatment read the next page carefully. If one of your loveones or friends that you care about is dealing with any type of cancer and are desperate for complete healing, go take a look at this site One minute cure.

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Mesothelioma - Ayurvedic Herbal Treatment

Mesothelioma is a rare form of cancer which develops from the protective lining that covers the internal organs of the body such as the lungs, the abdominal cavity and the heart. Environmental or occupational exposure to asbestos is mainly believed to be the cause for this condition. The commonest presentation of malignant mesothelioma is in the pleura which covers the lungs. Common symptoms include breathlessness, chest pain, collection of fluid in the pleura, and general symptoms such as weight loss. Diagnosis of this condition is usually done with the help of chest x-ray, CT scan of the chest and biopsy of the pleura. Signs and symptoms of mesothelioma appear nearly 20 to 50 years after exposure to asbestos. The cancer can spread to other parts of the body and produce different local symptoms. The modern management of this condition involves surgery, chemotherapy, and radiation, or a combination of these treatment modalities; however, the overall results are quite poor even with combined treatment. Survival after a confirmed diagnosis of this condition is an average of 1 to 2 years. Exposure to asbestos can have medico-legal implications and this condition is usually associated with lawsuits, seeking compensation for the condition.
Ayurvedic herbal treatment for mesothelioma is aimed at treating the tumour, preventing its spread to other parts of the body, and improving the overall survival rate. Ayurvedic herbal treatment can also be combined with modern management such as surgery, chemotherapy, and radiation therapy. Because of the aggressive nature of mesothelioma, Ayurvedic herbal treatment needs to be instituted at the earliest possible. Ayurvedic herbal medicines are required to be given in high doses and for prolonged periods in order to control this condition. Since the commonest presentations of this disease is in the pleura covering the lungs, herbal medicines which have a specific affinity for the lungs and the pleura are used as the mainstay of treatment in the management of this condition. In addition, herbal medicines which have a specific action on the blood tissue are also used in the management of mesothelioma. Medicines are also used to prevent the spread of this condition through the blood and lymphatic circulation. The medicines which are most useful in the management of this condition have an anti-inflammatory effect as well as an anti-cancer effect. The use of such medicines therefore helps in controlling inflammation, infection, as well as actually killing and removing the cancer cells.
In addition to the above treatment, Ayurvedic herbal immunomodulatory agents are also used in high doses in order to boost the immune system of the affected individual so as to help fight against the cancer and bring about a complete remission of the condition at the earliest. A strong immune system also helps to maintain the strength of the affected in individual and brings on a feeling of vigor and vitality. Depending upon the presentation of the disease, symptomatic treatment is also given for symptoms such as chest infection, fever, hemoptysis, pneumothorax, and the formation of pus in the pleural fluid. Herbal medicines also need to be given to flush the dead cancer cells, toxins, and debris generated in the treatment either through the gastrointestinal system or through the kidneys. Medicines useful in the treatment of Mesothelioma include Kantakari (Solanum indicum), Manjishtha (Rubia cordifolia), Saariva (Hemidesmus indicus), Guduchi (Tinospora cordifolia), Gokshur (Tribulus terrestris), Amalaki (Emblica officinalis ), Kanchnar Guggulu, and Mahamanjishthadi Qadha.
Most individuals affected with mesothelioma require aggressive Ayurvedic herbal treatment for about 12 to 15 months in order to comprehensively control the condition and significantly improve the survival rate. Ayurvedic herbal treatment thus has a significant contribution to play in the management and treatment of mesothelioma.

Dr. A. A. Mundewadi is Chief Ayurvedic Physician at Mundewadi Ayurvedic Clinic based at Thane, Maharashtra, India. He is available as an online Ayurvedic Consultant at http://www.ayurvedaphysician.com
The online clinic offers Ayurvedic treatment for all chronic and refractory health problems. Dr. A. A. Mundewadi, B.A.M.S., has clinical experience of over 25 years and clinical research experience of 12 years. He has conducted extensive research in HIV infection, Schizophrenia and many other chronic diseases.

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Mesothelioma Survival Rate - Bad!

Mesothelioma Survival Rate is not high and on average people diagnosed live from 4 to 11 months after. This survival rate is just harsh reality and devastating to the patients and their families. Sad is this fact as well that there are around 3,000 new diagnoses a year. However, new experimental treatments are being worked on to increase that number. See, this is good news because you get to spend that much more time with your loved ones. The American Cancer Society has been quoted to say that 40% of the patients now diagnosed with mesothelioma not live longer than a year and an average 10% live longer than 5 years.
The estimating or predicting, or attempt to do so, for anyone is difficult and there are some factors to take into consideration. Plus, the fact that no two patients are alike and what is true for one is not for another. The first factor that affects the individual's mesothelioma survival rate is the latency period.
The latency period is a big factor in the mesothelioma survival rate. This period is the amount of time from the time of exposure to asbestos and the first symptoms of mesothelioma. The time span between the two, or latency period, is anywhere from 20 - 50 years. This is a very long time for any disease to establish and when doctors finally do diagnose the health issues of the patient as mesothelioma, unfortunately it has spread to an advanced stage.
My question I have, that was not answered by any of my research is:
Why not go to your doctor before the symptoms begin, and you are still in the latency period. Talk to them, inform the doctor you worked with asbestos and what can they do to stop mesothelioma from taking your life?
Another factor in the mesotheliom survival rate of the asbestos exposed is the stage it is in when they are diagnosed.
Stage 1 and 2 have a better rate of survival because the disease has been caught early.
Stage 3 and 4 have a lower survival rate due to the advanced cancer growth and fewer treatment options available. Treating a cancer that has spread to other organs is an almost impossible battle to win inside the human body.
So, to recap, we have learned here that our mesothelioma survival rate goes up with the earlier diagnosing of it. I say, go to your doctor if you work with, or have worked with or around asbestos products. Learn the symptoms, educate yourself, this will help you in the end.
Other factors in the survival rate are:
· Age of the patient when diagnosed
· Does the patient smoke
· Health of the patient at diagnosis
· Size of tumor and if it has spread or can be removed
Treatments can improve Mesothelioma Survival Rates among some patients. Some of these treatments being rather aggressive such as surgery, chemotherapy, radiation help some people. Remember though this varies from person to person. For some these therapies help, for others it does not.
Some survivors have had success with alternative therapies which aim to strengthen the immune system and boost their well-being. Some of these therapies are acupuncture, massage, yoga, nutritional supplements.
Mesothelioma Survival Rates are not good and that is a sad fact. However we can increase the time we have with out loved ones who have this dreaded disease and more time is always a good thing.

I am sorry that I need to reveal to you the very low Mesothelioma Survival Rate, if it is any consolation, I have been in your shoes of having a loved one diagnosed with this disease.
It makes me hate the material of Asbestos and the destruction Asbestos Poisoning does to the body and our loved ones. I know the hate for a fiber is not healthy and does me no good and I will not hold onto it.

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Mesothelioma - All About It

Mesothelioma also commonly referred to as malignant mesothelioma, is an odd type of cancer which grows in the protective lining which shells most of the body's inner organs, the mesothelium. The cancer is as a result of exposure to asbestos.
The cancer usually develops on the pleura (i.e. the exterior lining of the lungs as well as interior chest barrier). Nonetheless, the cancer can also grow in the peritoneum (the coating of the abdominal cavity), the tunica vaginalis (a bag which environs the testis) or the pericardium (i.e. the pouch which surrounds the heart).
A majority of individuals who acquire mesothelioma have at one point in their lives worked on professions where they breathed in asbestos as well as glass specks, or were exposed to asbestos dust along with fiber by other means. It has also been shown that cleaning the garments of family members who worked with asbestos can put the person doing the laundry at risk of suffering from mesothelioma. While it is true that smoking can enhance one's chances of suffering from other types of asbestos-stimulated cancers, there is no medical proof to show that there is a link between mesothelioma and smoking. Individuals who have been subjected to asbestos have already accumulated harm for asbestos-related illnesses which include mesothelioma. Payments from asbestos funds or litigation are a critical matter in law practices concerning mesothelioma.
The signs that someone is suffering from malignant mesothelioma consist of shortness of breath as a result of pleural effusion (i.e. the fluid in-between the lung and chest barrier) or chest barrier pain, on top of general signs, for example, weight loss. The diagnosis can be identified with chest x-rays coupled with CT scan, and is verified with a biopsy (tissue test) on top of microscopic analysis. A thoracoscopy (this is where a tube with a camera is inserted into the chest) can be utilized to get biopsies. It enables the insertion of substances, for instance, talc to destroy the pleural space (known as pleurodesis), that deters more fluid from gathering and surging on the lung. In spite of therapy with chemotherapy, radiation and at times surgery, the mesothelioma has a bleak prognosis. Studies regarding screening examinations for the early prognosis of mesothelioma are still going on.
Signs and Symptoms
The signs and symptoms of mesothelioma might not show until twenty or fifty years after the initial exposure to asbestos. Shortness of breath, coughing and aches in the chest, as a result of gathering of fluid in the pleural space, are some of the most common signs of pleural mesothelioma.
Signs of peritoneal mesothelioma are weight loss, intestinal swelling along with aches as a result of ascites (this refers to accumulation of fluid in the intestinal cavity). Other signs of peritoneal mesothelioma might include bowel blockade, anemia, blood clotting irregularities as well as fever. In case the cancer has spread further than the mesothelium to other areas of the body, signs might be aches, issues with ingesting, or swelling of neck or face.
These signs might be triggered by mesothelioma or by other disorders that are less grave.
Mesothelioma which touches on the pleura can create the following signs and symptoms:
- Chest barrier aches.
- Coughing, wheezing and hoarseness.
- Exhaustion or anemia.
- Difficulties in breathing.
- Pleural effusion (i.e. fluids which environs the lung).
- Traces of blood in the sputum coughed out.
In acute cases, the individual might have numerous tumor heaps. The person might also develop a pneumothorax (collapsing of the lung). Over time, the illness can metastasize or spread to other areas of the body.
Tumors which affect the intestinal cavity frequently do not trigger signs till they are at a later stage. The signs and symptoms might include:
- Intestinal aches.
- Weight loss.
- Issues with bowel movements.
- A load in the abdomen.
- Uncharacteristic accumulation of fluid in the belly.
In acute cases of illness, the following signs and symptoms might show:
- Acute ascites.
- Low blood sugar level.
- Pleural effusion.
- Clotting of the blood in the veins which may in turn trigger thrombophlebitis.
- Disseminated intravascular coagulation. In a layman's term, this refers to a condition resulting in acute bleeding in numerous body organs.
- Jaundice. This refers to the yellowing of the eyes as well as the skin.
- Clotting of the blood in the arteries of the lungs.
Unlike other types of cancers, mesothelioma does not normally invade the brain, adrenal glands or the bone. Pleural tumors are normally located on one side of the lungs.
What causes mesothelioma?
The main cause of mesothelioma is exposure to asbestos. In the U.S., asbestos is the main cause of malignant mesothelioma and is regarded as "incontrovertibly" related to the growth of mesothelioma.

Click here to learn more about mesothelioma or visit us at www.asbestosmesotheliomacancer.net.

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When spread in lung cancer brain, bone, and other areas

Treatment of non-small cell lung cancer (NSCLC) who caught the disease in its early stages is usually successful. You can to leave it is localized in the lungs, surgical removal. Depending on the degree of lung tissue has impacted that location the surgeon can wedge resection, Lobectomy, pulmonary Prostatectomy surgery. Has spread beyond the lung unfortunately, large percentage of cases does not recognize disease until. This is a process known as metastasis. For curing conditions when it occurs, surgery alone is incorrect.

In this article, we will spread to other areas of lung cancer, how to learn. Learn to use medical treatment options are on the way to solve the disease.

The beginning of the transition

NSCLC tumors are cancerous cells so composed. These cells will eventually break from a tumor and travel to other parts of the body. Patients and their blood lymph system (part of the immune system), that can be done through.

Lung cancer is to explain in the context of the lungs is known as a primary tumor or cancer. Explain in the context of the area outside the lungs, and it is called a secondary cancer. Otherwise spreading NSCLC brain, for example, the surgeon "brain tumor pulmonary secondary" as rather "brain cancer to". This reference may actually dealing with transition occurs, and shows the former site of disease.

Spread of cancer cells in lymph nodes

Lymph node is first lung cancer cells to migrate. Cells are delivered through the lymphatic system. Moved to the early stages of the disease cell, for many this transition and are not necessarily. However, once cancer cells in lymph nodes, they can be distributed to other areas of the chest.

Does not exist, so this spread's doctor is almost caught symptoms. Lymph nodes of NSCLC has been detected that it treat chemotherapy is usually used.

Lung cancer-bone

Metastasis to the bone is common, and estimation of effects and 4-10 people late NSCLC stage the. Could be anywhere, entire body to the bone disease spread common site contains the upper legs, pelvis and spine. Patients experience pain worse disease advances. Miss pain of minor sports injuries such as people's muscle tone it is common.

Upon reaching the lung cancer bone it than treating disease symptoms relaxation treatment focuses on the progress to the point. Radiation therapy is the usual choice of treatment options. Patient receives medicine in order to minimize the pain.

When the disease reaches the brain

Too many people suffer from late stage lung cancer, brain Metastasis occurs. This is a loss of some side effects, headaches, seizures, and adjustment. Symptoms are similar to NSCLC reached the brain stroke side effect.

Surgery to treat, includes several options, including chemotherapy, Stereotactic radiosurgery. This latter option provides a specific part of a high dose of radiation brain tissue.

Liver cancer cells

Often accidentally discovered the NSCLC late early liver disease. Time cancer cells have reached the liver condition that are typically considered at stage 4. No symptoms other than those patients already suffering from it. Other times, under the rib cage pain or nausea, patients feel.

Bone metastatic NSCLC as purpose to reduce the treatment liver disease symptoms. Surgery is almost done at this stage.

You can't transition, from lung cancer cells are only operating in other parts of the body to cure the disease. See if you suspect there NSCLC will discuss treatment options most appropriate to your doctor.

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You can determine the nail clipping leg lung cancer risk.

Even if you get this... the smoker doesn't test your toenail clippings can tell from exposure to tobacco in lung cancer risk!

It is diagnosed and toenail clippings 210 Plus 630 as disease free men's control is using the test results. For this study, toenail clippings, research was donated in joining health care workers.

Why use all kind of toenail

To find a way to measure secondhand smoke exposure researchers were trying. It is thought that attempting to measure hair nicotine levels of their toenail clippings researchers from researchers found they could be useful. You may be able to analyze the nicotine to form hair and nails from the same types of organizations, so.

Toenail nicotine exposure last year to represent, and the benefits include not having special storage arrangements. Nail fastest leg of young people and men of us, all during the summer months grow.

Before surprisingly clippings given six years to smoking toenail nicotine level team of reliable gauge. It is also to predict the risk of heart disease in women. Toenail nicotine levels best women 42% greater chance of heart disease was compared with the lowest nicotine levels.

Crop of 20%, highest level of nicotine at greatest risk of male cancer development showed. They are 20% crop of the minimum amount of nicotine in this form of cancer of the participants greater chances of compared to 10. This was a time of 5. Have been diagnosed with lung cancer compared with the minimum amount of these toenail nicotine at the highest nicotine level accounting of non-smoking, male, foot-nail 3. Had 5 times the risk.

In cancer, is one of the worst types, lung cancer, men and women. Lung cancer of breast, colon and prostate cancer combined more than die. Older people of the most common cancer 45-year-old is rare.

We know that certain tobacco is leading cause of lung cancer smoking. The cause can prevent habit and start source of secondhand smoke to avoid.

I think there is a valuable way to predict whether or not researchers and measure patient exposure now, we are exposed to the risk of lung cancer, smoke or passive smoking. Exposure to smoke which amazing, under your right foot can detect your body for all.

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You can help the mesothelioma tumor lawyer bailout.

Mesothelioma Cancer carries the cause or source of a global epidemic for the very high risk. Continuous exposure to asbestos, the main causes of the disease has been proven. For the who global asbestos unsafe working environments is exposed. Millions of people in the world and the construction work in industries such as metal electrical works and repair shops, shipyards building location. High risk of exposure to toxins in the air can easily be sucked into these people.

Actually made in recent years, but the risk of transmission of this disease second hand, to a completely new level. Is company's responsibility to verify that it definitely, and provide a safe working environment for their employees ignores the danger or refused. However, history has shown us; corrupt officials with various companies to cover these facts more time to do our best. However, you can get good Mesothelioma lawyer, affected people deserve rewards. It is after all, 4-6 month survival time diagnosis after is a deadly disease.

Litigation insights

Affected individuals or manifestation of the level of risk to provide adequate safety environment did not you filed a lawsuit against the company and his right of no slip. Because of the fact, however, best asbestos litigation tort case in the history of American law related these cases are very common and has become highly skilled.

Lawyer offers technical information from more case-by-case. Malignant mesothelioma, contracted parties affected before the defendants are also always he started working in his company, already trying to point out that had the. I trust their claims or to lower compensation possible. However, you can do enough research and medical history of the person's claim in reality. Is a lawyer to verify the working environment thoroughly and case studies of asbestos professionals to bring it up.

Lawsuit takes some time, but people millions of dollars in compensation has been awarded. Hired from highly toxic asbestos actually disturbing case in New York, leading to death of businessman and high level of exposure, industrial sites to remove homeless people. Only in this case to process criminal proceedings paid financial compensation. In addition, were handed long exacerbate misery defendants prison sentences.

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MolMed starts Phase III trial of NGR-hTNF in mesothelioma

MolMed S.p.A. (Milan:MLM) announces the treatment of the first patient in a pivotal Phase III trial (NGR015) of its investigational antitumour drug NGR-hTNF in malignant pleural mesothelioma, a condition linked with repeated exposition to asbestos fibers.

Claudio Bordignon, MolMed’s chairman and CEO, comments: “We are really proud of this important milestone, as NGR-hTNF may represent a novel treatment option for malignant mesothelioma, a disease with very high unmet medical need. Based on the positive results of a multicentre Phase II trial, this Phase III trial is optimally designed to investigate the full therapeutic potential of NGR-hTNF in the treatment of mesothelioma.”

NGR015 is a pivotal randomised, double-blind, placebo-controlled, international multicentre Phase III trial, expecting to enrol 400 adult patients affected by malignant pleural mesothelioma with disease progressing after a pemetrexed-based chemotherapy. The trial investigates the administration of NGR-hTNF plus best investigator’s choice (BIC) versus placebo plus BIC, where BIC includes either supportive care alone or combined with one chemotherapeutic agent (either doxorubicin, or gemcitabine, or vinorelbine). Randomisation ratio will be 1:1. Before randomisation, investigators decide for each patient if he/she is candidate to either supportive care alone or combined with chemotherapy; patients are then randomly assigned to either of the two treatment arms by specific stratification factors.

NGR-hTNF is given intravenously as 1-hour infusion at 0.8 µg/m2 once a week, until disease progression; placebo follows the same administration schedule in the control arm. BIC is delivered, where applicable and as appropriate, according to Institutional and literature guidelines, and chemotherapy is administered as per standard clinical practice. The primary endpoint of the trial is overall survival. Secondary endpoints include progression-free survival, disease control rate, safety, and patient quality of life.

In a completed Phase II trial (NGR010), a single-arm, open-label, multicentre trial, NGR-hTNF was administered as monotherapy – either every three weeks or every week – in 57 chemo-pretreated patients. The results, presented in 2009 at ASCO and ECCO-ESMO, showed an overall disease control rate of 46% with a median duration of 4.7 months. The comparison of progression-free time between the weekly and the tri-weekly cohort showed a clear advantage of the treatment intensification approach (9.1 vs 4.4 months): accordingly, the weekly schedule was chosen in designing Phase III trial NGR015.

Also on the basis of Phase II results, in 2008 NGR-hTNF has been granted Orphan Drug designation for the treatment of malignant mesothelioma, in both the EU and the US.

MPM is a form of cancer that is almost always caused by repeated exposition to asbestos fibers. With an incidence of approximately 1/100,000, MPM is still a relatively rare type of cancer, but has been progressing fast in the past 20 years as incidence rates have continuously increased. MPM has a long latency period of the disease, and symptoms are non-specific, so that in most cases diagnosis is difficult before the advanced stage of the disease is reached. Treatment of malignant mesothelioma using conventional therapies has not proven to be successful, leaving affected patients with a poor prognosis and limited survival time.

NGR-hTNF is a vascular targeting agent with unique mode of action, and a first-in-class compound in the class of peptide/cytokine complexes able to selectively target the tumour vasculature. It consists of a tumour homing peptide (NGR) that selectively binds tumour blood vessels, fused to the human cytokine TNF. NGR-hTNF is undergoing clinical development both as monotherapy and in combination therapy, in a total of six indications. In addition to mesothelioma, NGR-hTNF has been tested as monotherapy in Phase II trials in liver and colorectal cancer. Phase II trials in combination therapy include: with Xelox for colorectal cancer; with doxorubicin for small-cell lung cancer, and for ovarian cancer; with cisplatin-based regimens in a randomised trial for non-small cell lung cancer, versus chemotherapy alone. MolMed is also conducting a Phase I trial aimed at the exploration of safety and preliminary anticancer activity of NGR-hTNF at high doses. In addition to mesothelioma, NGR-hTNF has
been granted Orphan Drug designation – in both the EU and the US – also for the treatment of liver cancer.

MolMed S.p.A is a biotechnology company focused on research, development and clinical validation of novel antitumour therapies. In addition to NGR-hTNF, MolMed’s pipeline includes another anticancer therapeutic in clinical development, TK, a cell-based therapy enabling bone marrow transplant from partially compatible donors, in Phase III for high-risk acute leukaemias. MolMed is headquartered at the San Raffaele Biomedical Science Park in Milan, Italy. The company’s shares (MLM) are listed at the Standard segment (class I) of the MTA managed by Borsa Italiana.

This press release is written in compliance with public disclosure obligations established by CONSOB (Italian securities & exchange commission) resolution no. 11971 of 14.5.1999 as subsequently amended.

For further information, please contact:

Holger Neecke Director Business Development, Investor Relations MolMed S.p.A. e-mail: investor.relations@molmed.comElena Lungagnani Communication Manager MolMed S.p.A. e-mail: media.relations@molmed.com

MolMed’s English language web site: http://www.molmed.com/eng/index.asp

 

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You must immediately remove the lung cancer and brain tumors

Be able to move about the cancer, body; you can affect brain activity after lung cancer.

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Around the Web has a ton of information scattered lung cancer it is depressing to somewhat it can know we know. Other benefits would have to survey compilation all. I puts many months of research, a useful guide. Price is of course not simplicity thanks. In the MyLungCancerGuide.com. You'll find this article about brain cancer of the lung and other very straight forward informative articles while there are.

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You may be affected by the bias of early lung cancer.

According to the findings of adult 1,500 Americans were reported by ABC News "majority of Americans, including many health care workers believe's illness because at least some people with lung cancer. ?

Reports say will lead to this bias of the diseases is the number 1 of cancer deaths in this country as the resources go, fight disease, despite reduced. It is also feeling shame and guilt are already difficult situations cancer adds to the patient's face.

Quote the ABC story Laurie Fenton Ambrose, President and CEO of Lung Cancer Alliance. Article is Ambrose state the following.

"Sadly, stigma under-funded studies alone for programs for early detection and treatment of has been used to justify. ?

This response probably, in part, for non-smoking campaign success.

Most people learned is a major cause of lung cancer is smoking. Unfortunately, many of them are leaps into believing that the cause of the non-smoking only is displayed.

Male lung cancer nearly 90% of deaths and about 80% of female lung cancer deaths caused by smoking.

However, that is, Americans is approximately 161 people of lung cancer die not smokersof should give pause to keep bias so that thousands of people.

If you have not developed the disease very much for non-smokers and smoking only cause justifying bias is difficult.

Non-smoking - 1 risk factor, but it's one and only one is not. Materials in other environments plays an important role in the history of similar families such as asbestos and radon exposure.

Workers blame would come every day for it to develop diseases come into contact with the substance, even many people, intentionally, is questionable. Also, most people poor dietary habits and sedentary lifestyle are several important risk factors for failure denies helping factor maybe Fund diabetes research.

It's obvious deserves the amount of attention breast cancer kills more people today lung cancer, malignant melanoma, kidney, prostate, liver, breast and colon cancer joins, at least to receive.

Follows the lives of far too many.

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ADAO Applauds Assembly Committee on Natural Resources for Passing Resolution to Repeal the Designation of Asbestos Laden Serpentine as the California State Rock

The Asbestos Disease Awareness Organization (ADAO) applauds both Senator Gloria Romero for authoring SB 624 and the Assembly Committee on Natural Resources for passing this legislation to remove serpentine, the host rock of asbestos, as California’s official state rock, supporting the eradication of asbestos to promote public health.

“ADAO dedicates our efforts on this campaign to Army Archerd, prolific Daily Variety journalist who died from mesothelioma in September 2009”

“California has the highest rate of mesothelioma deaths in the nation,” said Senator Gloria Romero (D-East Los Angeles). “This bill is about raising awareness to protect the health of our citizens. Serpentine contains asbestos, a known carcinogen. Toxic materials have no place serving as emblems for the State.”

Asbestos causes cancers and respiratory diseases such as mesothelioma, asbestosis, and lung cancer that claim 10,000 people every year in the United States and nearly 100,000 people worldwide. In 1965, serpentine was designated as the state rock of California in order to promote the then-lucrative asbestos mining industry. A practically indestructible lethal fiber, asbestos has been used for decades in numerous industries throughout California including building construction and naval shipyards, as well as in common household products ranging from crayons to blow dryers. Though asbestos is banned in 52 countries, it is not banned in the United States.

“ADAO dedicates our efforts on this campaign to Army Archerd, prolific Daily Variety journalist who died from mesothelioma in September 2009,” said Linda Reinstein, CEO and Co-Founder of the Asbestos Disease Awareness Organization. “A longtime fixture on the red carpet, Army’s death is unfortunately not unique and the death toll will continue until the United States Congress passes legislation banning asbestos. More than 7,000 Californians have died from asbestos-related diseases.”

On behalf of asbestos victims and their families, the John McNamara Foundation, and The Pacific Heart, Lung & Blood Institute, ADAO applauds our political leaders as this legislation moves forward to repeal serpentine as the state rock.

Asbestos Disease Awareness Organization (ADAO) was founded by asbestos victims and their families in 2004. ADAO seeks to give asbestos victims and concerned citizens a united voice to raise public awareness about the dangers of asbestos exposure. ADAO is the largest independent organization dedicated to preventing asbestos-related diseases through education and legislation. ADAO’s mission includes supporting global advocacy and advancing asbestos awareness, prevention, early detection, treatment, and resources for asbestos-related disease. For more information visit www.asbestosdiseaseawareness.org.

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Posted: Friday, June 25th, 2010 at 9:42 am; filed under Asbestos Disease Awareness Organization (ADAO), Asbestos Legislation, Organizations.

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Annual Asbestos Awareness Day Grows into a Global Asbestos Awareness Week

For more than a hundred years, knowledge of asbestos’ risks has been well documented. However, despite the seemingly widespread understanding that asbestos exposure kills, it was only seven years ago, on April 1, 2005 that the first "National Asbestos Awareness Day" was held.

Perhaps even more amazing is the comparatively short chain of events starting, in June of 2003, that led to asbestos awareness day.

Linda Reinstein had never heard of the mesothelioma when her husband, Alan, was diagnosed with it on the day after Father’s Day, June 16, 2003.

While on vacation, Alan began suffering from a cough that wouldn’t go away. Upon his return home, a trip to his doctor revealed a pleural effusion. Discovery of the pleural effusion led to a series of tests, misdiagnoses, and finally—after nine months—surgery.

The thoracic surgeon who performed the surgery found Linda in the waiting room; "are you alone?" he asked. Her heart sank.

The surgeon informed Linda that Alan had mesothelioma, a deadly cancer caused by asbestos exposure. He asked her if Alan had ever worked with asbestos.

"I had never heard of mesothelioma. I couldn’t pronounce it. And worse yet, I found that there was no cure," Linda recalls.

After surviving surgery to remove his left lung, pericardium, and diaphragm, Alan returned home to his wife and young daughter, Emily, to begin his recovery.

One day after coming home from school, the Reinstein’s 11-year-old daughter announced she wanted to go to Washington to "tell Senator Boxer and Senator Feinstein how hard it is for a girl who’s just 11 to watch her dad suffer."

"At that time, looking back," Linda says, "I had no clue how our life would change."

Linda and Emily traveled to Washington, asking for change. They hoped to prevent others from ending up in their position: watching a loved one die from a preventable cancer. They attending meetings with a photo of Emily and Alan dancing, and pointed out the dances and events asbestos exposure would rob from their family.

It was outside of these meetings, however, that Linda began to realize just how serious the problem of asbestos exposure was.

"It didn’t matter if we were standing in line for a Starbucks coffee or waiting for a taxi on our first trip, everywhere I went someone would say ‘are you just here for vacation?’" After explaining Alan’s diagnosis, inevitably the other person would share their own story of family member who had been diagnosed with an asbestos disease.

Linda found that asbestos diseases were not as rare as she had perviously been told, "they are just underreported."

Frustrated by the number of people injured by asbestos, the long history of knowledge about asbestos’ risks, and the lack of a ban on asbestos in products, the Reinstein’s took action. On April 1, 2004, less than a year after Alan’s mesothelioma diagnosis, Linda Reinstein co-founded the Asbestos Disease Awareness Organization (ADAO).

Among the goals of the ADAO was to "educate the medical community and concerned citizens regarding early detection, prevention, treatment and a cure for asbestos related diseases."

One year later, in 2005, the ADAO proposed a resolution designating April 1 as "National Asbestos Awareness Day." Nevada Senator Harry Reid (D-NV) and Tennessee Senator Bill Frist (R-TN) brought the resolution before the Senate Judiciary.

This year, nine Senators were listed as cosponsors and key supporters for the resolution declaring the first week of April as "National Asbestos Awareness Week."

Alan Reinstein lost his battle with mesothelioma in May of 2006. Surviving just shy of three years following his diagnosis was actually remarkable considering the 6-12 months most mesothelioma patients are estimated to have following a diagnosis.

After his death, Linda wondered "what now? Alan’s gone. Do we just give up with asbestos and mesothelioma?" However, remembering the promise Emily and Linda made to Alan to achieve a ban on asbestos, she reflected on what they’d deemed the Reinstein’s family motto: "Reinstein’s don’t give up."

"We persevered. We’ve now become the largest asbestos victims organization in the United States."

The US and Canada remain the only industrialized countries that have not banned asbestos. Despite not yet achieving a US ban on asbestos, the ADAO continues to work with victims, communities, and legislators increasing awareness of asbestos’ dangers, protecting the rights of victims, and working toward an asbestos ban.

This year, the ADAO will host its Seventh Annual International Asbestos Conference on April 1-3, 2011 in Atlanta, GA. Experts, patients, and their families will discuss the public health, environmental, and economic impacts of asbestos.

Thanks to growing interest in Asbestos Awareness Day, what was once a single day, has now grown into a "Global Asbestos Awareness Week." From an ADAO press release: "What started as a day has grown into a full week of international activities incorporating education, advocacy and community driven efforts to fuel a worldwide ban on asbestos and provide resources and hope to asbestos victims and their families."

For Emily and Linda Reinstein, the journey must seem long, lengthened by the pain of loss and the frustratingly slow winds of change. However, for the millions of people injured by asbestos over the last 150 years, the Reinstein have, in just a few short years, brought new levels of awareness, education, and research to legislators and the public, and hope to asbestos victims and their families.

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Posted: Monday, March 28th, 2011 at 5:38 pm; filed under Asbestos Disease Awareness Organization (ADAO), Asbestos Legislation, Full Archive, Organizations.

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The early diagnosis of mesothelioma is the key

Mesothelioma has become one of the deadliest viruses of the last three decades. The root of the virus is found in exposure to asbestos material. Even if the disease is considered to be less prevalent in relation to other forms of cancer, such as lung cancer, it is disturbing to growth due to its airborne exposure mode, it has been quite lethal. There is still no cure for this form of cancer except chemotherapy. According to a report Malignant mesothelioma kills 10,000 people per year in the United States only.

The problem lies in the fact that there is no real alternative solution to asbestos. And since the end of the 70 companies that manufacture this equipment have always lied or ignored risk levels. But because thousands of cases of crime based on exposure to asbestos, manufacturing companies doing all they can to meet the standards of worker safety.

Transmission through asbestos

The connection of asbestos exposure has been proved that in years 70 are there sufficient data available to complete. The toxic nature of asbestos if inhaled over a long period of time leads to form of mesothelioma cancer. There are secondary transmissions or the case of on-line transmission. In 2004, a lady in England got infected mesothelioma due to the clothing of his father who has been exposed to high levels of this toxic material. This case creates a whole new level of risk that the person concerned was not directly working in an environment of asbestos.

The redemptive fact of exposure to asbestos is that transmission of malignant mesothelioma is not possible with small periods of exposure. Cannot get cancer if she inhales toxins a few times. Prolonged exposure to this environment may be the only cause of this disease. Centre for Disease Control (CDC) a person may take up to 7 to 10 years to develop mesothelioma

Diagnosis of the disease.

Early diagnosis is the key to the fight against this disease, so diagnosing a set of common symptoms as early as possible is highly recommended. It is mainly in the case of persons working in the high risk environment.

The following is the basic process used in the diagnosis of mesothelioma

(A) a review CT or MRI to verify the presence of large fluid

(B) the lung function test and a chest x-ray is done after a thorough physical check

(C) finally a biopsy is necessary for confirmation of malignant mesothelioma

Biopsy depends on where the cancer. More commonly, it is located in the chest or abdomen. Although no test is perfect, based on medical history and the possibility of exposure to asbestos, the person some conclusions can be drawn.

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Understanding a Mesothelioma prognosis

A prognosis of mesothelioma can vary from a variety of different patients. Some may experience difficult prognosis and others can receive better and more positive news. In any event, mesothelioma remains a very serious illness which comes with a high fatality rate. This is why legal action against those who place individuals at risk of contracting mesothelioma is so aggressive.

Mesothelioma derives from exposure to asbestos that was commonly pipes in previous generations. At the time, it was not regarded as a harmful substance. Over the past two decades, the fact that exposure to asbestos can cause cancer was revealed. As a result, property owners have the responsibility to have the asbestos detected and removed. Unfortunately, this has not always kept that leads to the unfortunate question of those suffering from this form of horrible cancer. Once a diagnosis has been made, then the patient must treatment.

Prognosis of mesothelioma occurs immediately after the patient learns that he has the disease. A prognosis can be considered a preview of what will be the cancer in the body. The prognosis of what will follow the course of cancer will be depends on many factors. Obviously, these factors will play a major role in if the prognosis is good or a bad thing.

One of the factors that may affect the prognosis is positive or not will be early detection. It takes more to cancer be detected, the worse the prognosis will be generally. This is because the cancer will continue to spread if it is not detected and treatment begins. If the cancer has invaded not significantly the capacity to deal with it is improved. This is why those who feel that they have been exposed to asbestos must take immediate measures and to communicate with their doctor for a full review.

Detection of mesothelioma will also determine where the cancer is in reality. If the tumor is located in a region of the body, it may be likely that it can be removed surgically. If tumours are spread throughout the body, then surgery may be complicated or potentially impossible.

Once the cancer was detected, the stage that cancer will be determined. There are four stages in a prognosis of mesothelioma with steps 3 and 4 being the most serious and most advanced. Any person who is currently in a stadium would have a difficult time beating cancer. Conversely, those who capture the condition early enough may be able to take the necessary measures to send the cancer in remission.

Again, this is why early detection is important when talking about the prognosis of mesothelioma. If the cancer can be captured in the earliest stages, the survival rate increases. Yet, no matter what date the cancer is detected, it will remain always deadly with no guarantee that the treatment will work. These information are not shown to be pessimistic. It is mentioned to explain the severity of the disease so that any person that may have been exposed to asbestos include the need to seek a correct diagnosis of a physician.

General health of the patient will play a role in prognosis. This does not mean that a person may be so healthy that the treatment will be "easier." However, a healthy person will have a strengthening of the immune system and will be able to manage the necessary treatment for cancer. It is not easy to survive mesothelioma. Some may find that the survival of five years or more is the maximum that they can achieve. Still, the overall health of the individual will play a factor in the ability to manage the treatment.

Those who have been exposed to asbestos through negligence and have been diagnosed with mesothelioma should consider their legal options. The reason is there are many costs associated with the treatment of mesothelioma with large financial burden due to the inability to work when they deal with this cancer. A prosecutor described with experience in management of mesothelioma would be the best professional work with in such a situation.

A prognosis of mesothelioma is serious. It requires immediate medical treatment and should also include the search for appropriate legal representation. This makes the ability to treat the condition more tolerable.

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The truth about the life expectancy for mesothelioma

Discuss the question of mesothelioma life expectancy is certainly not a pleasant. Still, it is a subject that must be discussed if you have been diagnosed with the State. In fact, it is also a subject which should be raised to those fearing they were exposed to asbestos and have not undergone a proper diagnosis by a physician. Once that person realizes the nature of the potentially fatal severe mesothelioma, it is doubtful that the individual will be wait longer for a correct diagnosis.

Once more, mesothelioma is a severe form of cancer. He took the lives of many people who have contracted it. Accordingly, it is essential to seek medical treatment as soon as possible as humanly possible that this will potentially increase the chances of survival of the person with cancer tumors.

The prospects of a person suffering from Mesothelioma will depend on several factors. The only way to determine these factors would be to undergo a complete examination designed to determine the severity of the condition. If the cancer was detected sooner or later; the stage of cancer; and if the cancer has spread through the body would be among the factors related to the life expectancy of how long a person will be.

So, although there is no guarantee that this is in terms of treatment success may be, early detection will have the greatest impact on the life expectancy for mesothelioma. The survival rate increases when effective treatment is instituted. Note: always treatment is more likely to be successful when cancer is found at an early stage.

I repeat, there is no way to determine uniformly cover mesothelioma life expectancy. However, there are statistics that allow researchers to examine the expectancy of average life of a suffering from this form of cancer. There are three major forms that Mesothelioma: pleural mesothelioma which affects the lungs. Peritoneal Mesothelioma which deals with the abdominal area. and pericardial mesothelioma, which is quite rare and touches the heart. A fourth form, testicular mesothelioma is extremely rare and not easily diagnosed. With the three major forms of cancer, mesothelioma life expectancy vary.

Pleural mesothelioma is a form of incurable cancer and if not detected and treated, the chances of survival range from four to 18 months. Peritoneal Mesothelioma yield five months to 13-month outlook if it is not treated. Because the pericardial mesothelioma is so rare and research is limited, an estimate of the duration of average life when not treated not is very difficult to determine.

Of course, with appropriate treatment, possibility to considerably extend of life is possible. This is because treatments such as chemotherapy and radiotherapy can slow growth and the spread of the cancer cells. Chemotherapy and radiotherapy can, potentially, destroy cancer cells. Surgery can be used to remove purely and simply the cancerous tumours. The possibility of using combinations of two or three methods remains an option as well.

As mentioned above, there will be a variety of factors that contribute to effective processing capacity. The absence or presence of other diseases or disorders may play a role in the effectiveness of the treatment may be. In some cases, issues such as the actual location of cancerous tumours can determine that the employee treatment which, in turn, will affect life expectancy. An example of which would be the presence of tumors near the heart. The high risk to perform surgery in a region often eliminate the examination procedure. The impact on life expectancy when procedures are reduced could possibly be negative.

Of course, a patient must do his part to extend life expectancy. Life choices can significantly impact how long or short your life expectancy is how. For example, someone who continues smoking after diagnosis of mesothelioma will significantly reduce its life expectancy. As such, it is well advised to follow all suggestions of way of life made by a physician, if the objective is to increase the life expectancy for mesothelioma.

The possibility of extending the life expectancy for mesothelioma is never guaranteed. However, there are certainly ways this can be done. However, the decisions shall be taken on a case by case.

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The three principal organs affected by Mesothelioma

Mesothelioma is a rare type of cancer that develops in the lining of large internal organs. It is caused by exposure to asbestos. Because asbestos fibres are tiny, they become lodged in the wall organs internal and, over time, lead to the growth of cancerous tumours. The time period between asbestos exposure and mesothelioma cancer onset may be several decades, this is why many patients fail to recognize the early symptoms of the disease. Unfortunately, this leads to a delayed diagnosis of mesothelioma, which in turn reduces the life expectancy of the patient.

Patients often develop mesothelioma were exposed to asbestos in their place of work, such as the marine shipyards and construction sites. Repeated exposure to asbestos means that they inhaled millions of tiny asbestos fibres which have remained in their body. The three bodies most often affected by Mesothelioma are the lungs, heart and stomach.

Lungs: Pleural mesothelioma

The most common form of mesothelioma, known as pleural mesothelioma, affects the lungs. The disease results when the inhalation of asbestos fibers become deposited in the lining that surrounds the lungs and cause the growth of cancer cells around them. This process causes the lining of the lungs to fill with fluid, which interferes with respiration and causes pain in the chest. At this stage, pleural mesothelioma patients more notice that something is wrong and seek the assistance of a doctor.

Stomach: Peritoneal Mesothelioma

Asbestos fibers can also become lodged in the wall around the stomach. This type of mesothelioma, which is called Peritoneal Mesothelioma, occurs when a person eats food covered with asbestos fibres microscopic. The fibrous material remains in the stomach lining for a long time (20-50 years) until it prompts the growth of cancer cells. Peritoneal Mesothelioma is much more rare than pleural mesothelioma, accounting for about 10-20% of all mesothelioma cases.

Heart: Pericardial mesothelioma

Tiny asbestos fibres can also become lodged in the wall of the heart, where they can cause cancer. This form of mesothelioma is called pericardial mesothelioma. It is a very rare type of mesothelioma, accounting for approximately 10 per cent of all cases of mesothelioma.

Mesothelioma: Medical and legal considerations

The treatment of all forms of mesothelioma is similar and typically involves a combination of surgery, chemotherapy and radiation therapy. While aggressively administered mesothelioma treatment may slow the spread of the disease, can seldom heal. This is because most mesothelioma cancers are discovered at an advanced stage, when treatment is less effective.

If you have been diagnosed with mesothelioma or your loved one died of this disease, counsel competent mesothelioma can help you to hold those responsible for your responsible for suffering of your medical expenses, physical and psychological pain and decreased quality of life.

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The Symptoms of Mesothelioma

Mesothelioma is a form of cancer which is being discovered more and more frequently in elderly men.  The most common cause of mesothelioma is from asbestos exposure and affects the membrane of many of the most vital internal organs such as the lungs and heart.  Mesothelioma is particularly hard to diagnose because it shows similar symptoms to many other more common diseases.

The most common form of mesothelioma is called pleural mesothelioma.  This type of mesothelioma accounts for 75% of all mesothelioma cases.  Pleural mesothelioma affects the lining of the lungs and has symptoms such as chest pain, coughing, breathing and swallowing difficulties, shortness of breath, wheezing and weight loss.  These symptoms apply to many less serious diseases but anyone with signs of these symptoms are strongly advised to consult their doctor as soon as possible.

A less common form of mesothelioma is peritoneal mesothelioma and this form of the cancer affects the abdomen.  The tissue lining the abdomen is called the peritoneum and this is what is affected.  Peritoneal mesothelioma accounts for 20% of all mesothelioma cases. The symptoms of peritoneal mesothelioma are weight loss, abdominal pains, loss of appetite, weakness, nausea, and abdominal swelling.  These symptoms become more and more severe as the cancer develops.  To learn more about these symptoms go to http://www.1-mesothelioma.co.uk

Those who are exposed to asbestos or have been exposed have a risk of obtaining mesothelioma.  It is important that mesothelioma is diagnosed in its early stages so that it can be treated quickly and aggressively.  The earlier it is discovered, the more likely the treatment will be successful.

All the detailed information you need on the symptoms, treatment, risks, science and more about mesothelioma can be found at: http://www.1-mesothelioma.co.uk

Be sure to visit to learn more about this deadly cancer and how you can prevent it.
[tags]Mesothelioma, Symptoms of Mesothelioma, Symptoms, guide-to-mesothelioma.com[/tags]

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Raltitrexed (Tomudex®) in Combination With Cisplatin in the Treatment of MPM Improves Overall Survival Compared to Treatment With Cisplatin Alone

Tuesday, October 12th, 2010.

Raltitrexed (Tomudex®) in Combination With Cisplatin in the Treatment of MPM Improves Overall Survival Compared to Treatment With Cisplatin Alone1MPM is a Rare Cancer, but its Incidence is Expected to Double Over the Next 20 Years in Many Countries2Raltitrexed is Currently Licensed for the Treatment of MPM in Portugal, Czech Republic and Hungary; Further Marketing Authorisations are Expected Across Europe in Late 2010

Raltitrexed (Tomudex®) in combination with cisplatin in the treatment of MPM improves median overall survival compared to treatment with cisplatin alone.1 With incidence rates expected to double over the next 20 years in many countries2, new and effective treatments are a welcome addition, concluded an eminent panel of international speakers at a symposium sponsored by Hospira at the 35th congress of the European Society for Medical Oncology (ESMO), Milan.

Mesothelioma is a form of cancer that affects the mesothelium, a thin membrane that lines the inner surface of the chest wall where it is known as the pleura. It also surrounds the organs found within this cavity, for example the heart and lungs.3 Speakers at the symposium highlighted that whilst MPM – most commonly caused by exposure to asbestos – is a rare disease (the incidence is estimated to be 1.1-1.25 cases per 100,000 people), its incidence is expected to double over the next 20 years in many countries.2

Historically MPM has been treated with radiotherapy or surgery, despite minimal evidence to support these treatment options and both being associated with low success rates.4,5,6 Speakers highlighted that over recent years the treatment of MPM has been simplified with the development of chemotherapy regimens as first-line treatment options.

Speakers referred to a clinical trial of first-line raltitrexed in combination with cisplatin, which showed that overall response rates in the raltitrexed group were higher compared to patients treated with cisplatin alone (23.6% vs. 13.6%; p=0.056).1 Raltitrexed improved median overall survival by 2.8 months compared to patients treated with cisplatin alone (11.4 vs. 8.8 months; p=0.0483).1 In addition, raltitrexed was associated with improved progression-free survival (5.3 vs. 4.0 months; p=0.058) compared to treatment with cisplatin alone.1

"MPM is a hard to treat, rare cancer with a poor prognosis. New treatment options such as a combination of cisplatin and raltitrexed, which improve patient outcomes with no detrimental effect on quality of life as compared to cisplatin alone are a welcome addition to our therapeutic portfolio," said Professor JP van Meerbeeck, professor of Thoracic Oncology at Ghent University, Belgium.

Treatment of MPM with chemotherapy regimens, including those that are cisplatin-based, is associated with a high incidence of neutropenia and anaemia. Neutropenia is the most serious haematological toxicity that occurs as a result of cancer chemotherapy and can lead to chemotherapy dose reductions and/or dose delays compared with the prescribed schedule.7 Anaemia is associated with fatigue and poor quality of life. Supportive care to treat neutropenia and anaemia is therefore very important. Hospira has a broad oncology portfolio including supportive care drugs: Nivestim™ (filgrastim) and Retacrit™ (epoetin zeta), which are licensed for the treatment of chemotherapy-induced neutropenia and anaemia respectively.

Tomudex (Raltitrexed) is currently licensed for the treatment of malignant pleural mesothelioma (MPM) in Portugal, Czech Republic and Hungary; further marketing authorisations are expected across Europe late 2010. Mesothelioma is a form of cancer that affects the mesothelium, a thin membrane that lines the inner surface of the chest wall where it is known as the pleura.

Nivestim (filgrastim) was recently approved by the European Commission for the reduction in the duration of neutropenia and incidence of febrile neutropenia in patients undergoing established chemotherapy for malignancy. Neutropenia is a condition where the number of neutrophils (a type of white blood cell) in the blood is abnormally low. A reduced number of neutrophils increases a patient’s susceptibility to bacterial and fungal infections.

Retacrit (epoetin zeta) is indicated for the treatment of chemotherapy-induced anaemia, and anaemia associated with chronic renal failure. Epoetins such as Retacrit, are forms of erythropoietin, a hormone produced by the kidneys which acts within the bone marrow to stimulate red blood cell production. There are many causes of anaemia, including chemotherapy treatment for cancer (which indiscriminately inhibits all fast-growing cells, including red blood cells), renal failure (which can cause a deficiency in production of erythropoietin) or a decrease in bone marrow function. A decrease in red blood cell number or function may lead to anaemia. Retacrit has been available in Europe since 2008.

Hospira is a global specialty pharmaceutical and medication delivery company dedicated to Advancing Wellness™. As the world leader in specialty generic injectable pharmaceuticals, Hospira offers one of the broadest portfolios of generic acute-care and oncology injectables, as well as integrated infusion therapy and medication management solutions. Through its products, Hospira helps improve the safety, cost and productivity of patient care. The company is headquartered in Lake Forest, Illinois, United States and has approximately 13,500 employees. The head office for Hospira in Europe, Middle East and Africa is in Leamington Spa, UK. Learn more at http://www.hospira.com.

van Meerbeeck JP, Gaafar R, Manegold C, et al. Randomized phase III study of cisplatin with or without raltitrexed in patients with malignant pleural mesothelioma: an intergroup study of the European Organisation for Research and Treatment of Cancer Lung Cancer Group and the National Cancer Institute of Canada. J Clin Oncol. 2005;23(28):6881-9Stahel RA, Weger W, Lievens Y, Felip E. Malignant pleural mesothelioma: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up. Ann Oncol 2010; 21:v126-8Mesothelioma UK website. http://www.mesothelioma.uk.com/mesothelioma-information-support.htm. Accessed 15 September 2010Borasio P, et al. Malignant pleural mesothelioma: clinicopathologic and survival characteristics in a consecutive series of 394 patients. Eur J Cardiothorac Surg 2008;33:307-13Lee C, et al. Prophylactic radiotherapy to intervention sites in mesothelioma: A systematic review and survey of UK practice. Lung Cancer 2009;66:150-6Scherpereel P, et al. Guidelines of the European Respiratory Society and the European Society of Thoracic Surgeons for the management of malignant pleural mesothelioma. Eur Respir Journal 2010;35:479-495Crawford J, Dale DC, Lyman GH. Chemotherapy-Induced Neutropenia: Risks, Consequences, and New Directions for Its Management. Cancer, 2004; 100(2): 228-37

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Application of mesothelioma

If you or a family member recently received a diagnosis of mesothelioma, you probably want to know what help is available for those in your position. Apart from the obvious support, you will need to disease and trauma surrounding it, you may be eligible to claim compensation for mesothelioma. An allowance is paid when it is proven responsible for the disease. However, there are special rules to make a claim for compensation for mesothelioma and you must take legal as soon as possible.

In the case of a Mesothelioma claim, compensation is usually claimed to the insurers of the company who are committed a fault by allowing you or your family member, to come into contact with asbestos. Because mesothelioma can take between 30 and 40 years to develop after exposure to asbestos, in most cases, responsible companies ceased to exist many years ago but compensation would be requested from the insurers of the undertaking in question. The insurance companies need to trace accuse him to be proven and it is important that the legal advice be sought as soon as possible, which will increase your chances of getting compensation.

There are legal experts who specialize in claim mesothelioma and doing a quick search of the Internet, you should be able to find one in your community. A local law firm is not essential, but the experience to make the claims of mesothelioma is. Although at this time there will be several important issues on your mind, it is worth taking the time to address the issue of compensation to your liking earlier, you'll find the award very useful at a later date. Once you have obtained the services of a claim for mesothelioma expertise, they will deal with everything for you to pay, and you can get other pressing issues.

An application of mesothelioma will generally be compensation covering many elements. For example, the disease itself, the loss of income, necessary items due to illness, special food, mobility aids, care provided by the members of the family, care provided by professionals, hospital, etc. of travel expenses. All these additional costs you reimbursed will no doubt place a heavy burden on your financial situation, it is imperative that seek you professional advice and set the wheels in motion to get your claim for mesothelioma to current compensation.

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A Mesothelioma attorney can help you get relief

Cancer Mesothelioma has a very high risk of becoming a global epidemic because of its source or cause. Prolonged exposure to asbestos has been proven to be the first cause of this disease. Globally people are exposed to asbestos due to their dangerous working environment. Millions of people work in the world industrial places such as the electric construction of constructions, shipyards, metal shops and workshops and repair works. These people have a high risk of exposure to airborne toxins that can be easily inhaled.

In fact in recent years the secondary transmission of the disease has created a whole new level of risk. It is the responsibility of the company to provide a safe workplace for their employees and to ensure that the risks are not ignored or denied. But as history has shown. various companies and corrupt officials did their best to cover those facts a good number of times. But with a good mesothelioma Attorney, made people can obtain the compensation they deserve. After all, it is a fatal disease that has a duration of survival of 4 to 18 months after the diagnosis.

An overview of litigation

A person would be in its right to file a complaint against a company who are not providing an adequate security environment, or clear indication of the level of risk. However, the asbestos-related lawsuits are tort cases in the history of American law, these cases have become very common and very technical.

A prosecutor must provide much technical information of a case database to another. The defendant tries to always note that made party had already contracted malignant mesothelioma, even before he started to work in their business. They try to discredit the claims or less than the compensation as far as possible. But in reality, enough research and the person's medical history can help in the claim. It is for counsel to research in-depth in the case and even bring experts from asbestos and examine working environments.

Of the litigation process some time but people have been awarded millions of dollars in compensation. In fact, in a case disturbing in New York, a businessman hired homeless people to remove highly toxic asbestos of an industrial site which lead to high levels of exposure and of death. In this case, it was not only financial compensation has been paid but a criminal prosecution was brought into the process. In addition, to increase poverty, the defendants were given long prison sentences.

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Smoking and its effects on mesothelioma

Mesothelioma is a type of cancer caused by exposure to deadly asbestos fibres. Although it is a type of cancer that affects the plural lining of the lungs, it is not in fact lung cancer.

The prognosis for mesothelioma patients is poor. Because of the difficulty of detecting the symptoms and the extremely long dormant period, repeatedly mesothelioma is not diagnosed until it is too late. When a person is exposed to asbestos fibres, they become lodged in the pleura of the lungs where they will create scar tissue. This scar tissue will be finally transform carcinogenic and mesothelioma will occur. Many people, even if only exposed to asbestos for a short period of time, can contract this disease.

Although smoking is a very quick way to damage the lungs, it is important to understand that smoking causes not mesothelioma. However, smoking complicate the chances of a person to contract the disease. Smoking can cause mesothelioma not directly, but it may cause to other deadly diseases such as lung cancer, chronic obstructive pulmonary disease, emphysema and asbestosis. Asbestosis is not a form of mesothelioma, but it is useful in the development of cancer.

If a patient is diagnosed with mesothelioma, it is essential that they stop smoking immediately. The statistics surrounding smoking are devastating. Although smoking does not lead to mesothelioma, it increases the risk of contracting cancer of the lung by 50% or more! A patient is a smoker is more likely to have a disease linked to lung that a person who has been exposed to mesothelioma for several years. Prior it goes to show how damaging and serious are the effects of smoking on the lungs.

Mesothelioma and lung cancer caused by smoking are very serious because of their difficulty of detection. The severity and type of symptoms depend on many factors. For mesothelioma patients, the amount of inhaled asbestos and the extent of exposure will determine the side effects and severity of cancer. For lung cancer caused by smoking, the quantity of tobacco per day and how long a person has smoked will determine the side effects and severity.

A smoker who has been exposed to asbestos at any point in his life should be immediately tested for mesothelioma and other types of diseases linked to lung, even if the symptoms are non-existent. Still, it is important to understand that the mesothelioma and lung cancer are two distinct types of cancers, both with the lungs, or surrounding organs.

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Mesothelioma claim

Mesothelioma compensation is granted to the plaintiff when the defendant in such a prosecution admits or is held responsible for causing disease. Request compensation should always be paramount question to people suffering from this form of cancer. Yet many do not seek just compensation. Why is this? A common misconception about Mesothelioma or other medical related prosecutions is that they are intended to "vengeance" to be made. Such assessment is obtuse at several levels. The reason why the afflicted seek a settlement or judgment is due to the enormous costs associated with disease.

Mesothelioma is a serious condition because it is a form of cancer derived from exposure to asbestos. The exhibition is often derived from negligence. A form of negligence would be building owner or management do not properly screen for mesothelioma and those in the building has suffered from exposure. It is also not without precedent that those working in asbestos removal suffered from their exposure due to defective protective equipment.

Whatever the reason for exposure, mesothelioma is life-threatening. Send mesothelioma in remission, it will require all kinds of financial costs. It is the main reason why mesothelioma compensation must be sought after - costs associated with medical expenses must be covered. Without the best of care, it would become harder to overthrow the State.

Once again, this is why seeking monetary rewards is so important. The costs associated with treatment are so fresh said huge funding is a must if appropriate treatment is necessary. And why should not those responsible for the onset of the condition be held liable for the cost?

Once more, these costs may be considered important. In addition to medical treatment, bills can accumulate from other sources as well...

According to the stage of the disease, the afflicted may be unable to work. Although it was legitimately unable to work may raise the sympathy of some, the situation has not automatically with just a derogation for financial responsibilities. Without a viable flow of money, financial stress is bound to increase significantly. Efficient payments through an action in court or regulations could significantly reduce pressure associated with this financial strain.

Another area of the mesothelioma compensation which must be resolved would be one of the pain and suffering. Having to deal with the causes of mesothelioma pain and extreme discomfort may justify a financial compensation high rewards. The Act had recourse in place for those dealing with the suffering and sometimes in the form of civil judgment. Those who suffer from such a condition are well within their rights to seek such payments.

Questions will arise on the amount of compensation that may be granted. Cover answers to these questions are not really valid. There is no reward claire and set compensation for mesothelioma. Some judgments are large enough and others can be small. There are simply too many factors weigh into the manner in which prizes are awarded. The key here is that the afflicted seek a qualified and experienced attorney who specializes in these types of cases. In doing so, it increases the chance that appropriate payment is reached.

Payment can come in two forms. The first would be one out of the regulations of the Court and the other would be a judgment on a civil case. There is no better that the other and the decision to accept the settlement vs take the case of the civil court. There are a large number of factors that can enter into decision-making regarding how a particular dispute should move forward the process. To determine which direction to follow will be based on the situation of the litigant and needs and the advice of legal counsel. Regardless of your own individual situation, all those involved in a case of mesothelioma must seek the best outcome for their needs.

In short, they should seek the maximum amount of financial reward which can be acquired in a way that the litigant is more comfortable to continue. Discuss your specific options with a qualified lawyer will boost the likelihood that you follow the procedure to follow for your needs and your requirements.

Mesothelioma claim is a process which should not be taken lightly. There are a complex lot and make good decisions is factor in your ability to receive just and fair judgments. This is why proper deliberation must enter the process. To do otherwise could restrict claims hugely.

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The early diagnosis of mesothelioma is the key

Mesothelioma has become one of the deadliest viruses of the last three decades. The root of the virus is found in exposure to asbestos material. Even if the disease is considered to be less prevalent in relation to other forms of cancer, such as lung cancer, it is disturbing to growth due to its airborne exposure mode, it has been quite lethal. There is still no cure for this form of cancer except chemotherapy. According to a report Malignant mesothelioma kills 10,000 people per year in the United States only.

The problem lies in the fact that there is no real alternative solution to asbestos. And since the end of the 70 companies that manufacture this equipment have always lied or ignored risk levels. But because thousands of cases of crime based on exposure to asbestos, manufacturing companies doing all they can to meet the standards of worker safety.

Transmission through asbestos

That by the 1970s are there sufficient data available to complete the connection of exposure to asbestos has proved. The toxic nature of asbestos if inhaled over a long period of time leads to form of mesothelioma cancer. There are secondary transmissions or the case of on-line transmission. In 2004, a lady in England got infected mesothelioma due to the clothing of his father who has been exposed to high levels of this toxic material. This case creates a whole new level of risk that the person concerned was not directly working in an environment of asbestos.

The redemptive fact of exposure to asbestos is that transmission of malignant mesothelioma is not possible with small periods of exposure. Cannot get cancer if she inhales toxins a few times. Prolonged exposure to this environment may be the only cause of this disease. Centre for Disease Control (CDC) a person may take up to 7 to 10 years to develop mesothelioma

Diagnosis of the disease.

Early diagnosis is the key to the fight against this disease, so diagnosing a set of common symptoms as early as possible is highly recommended. It is mainly in the case of persons working in the high risk environment.

The following is the basic process used in the diagnosis of mesothelioma

(A) a review CT or MRI to verify the presence of large fluid

(B) the lung function test and a chest x-ray is done after a thorough physical check

(C) finally a biopsy is necessary for confirmation of malignant mesothelioma

Biopsy depends on where the cancer. More commonly, it is located in the chest or abdomen. Although no test is perfect, based on medical history and the possibility of exposure to asbestos, the person some conclusions can be drawn.

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What is Cancer mesothelioma, and how should it be dealt with?

What is mesothelioma, you might ask? Mesothelioma is a rare disease caused by malignant cancer cells that appear in the lining of body cavities of the individual, such as the chest, abdominal region and the area surrounding the heart. Mesothelioma is usually, but not always, associated with exposure to asbestos.

The symptoms of mesothelioma include shortness of breath, pleuritic pain lasting cough, fatigue and weight loss. The presence of these symptoms of mesothelioma do not necessarily mean that it has mesothelioma. They raise the possibility. However, these symptoms of mesothelioma, should never be ignored. They should be called to the attention of the doctor for diagnosis and treatment as soon as possible. Because the rate of recurrence of cancer cells is extremely high, it is very important that the disease is diagnosed and treated as soon as possible. Where one or more of these symptoms of mesothelioma are present, as soon as a person gets the doctor and the necessary tests done better.

If someone suffers the symptoms of mesothelioma, the doctor will likely want that they undergo a series of tests to verify if these symptoms are actually true indications of this rare form of asbestos cancer or if they point to anotherHopefully less serious problem. Medical tests that are usually ordered by a physician when these symptoms of mesothelioma occur several times will include CT scans, x-rays and MRI's.

It must be pointed out that whether a person should these symptoms of mesothelioma occur soon is verified by a better doctor. It is a form of cancer very fast acting and aggressive. Unfortunately, the symptoms of mesothelioma does not usually become apparent during the early stages of the disease when medical treatments are more effective.

If you or someone you know shows even one or two symptoms of mesothelioma, take precautions and don't wait for a medical doctor specializing in the situation as soon as possible. Don't put. For your own sake as well as for the good of your loved ones, you must take action immediately. Although it is very little likely that you've been stricken with mesothelioma cancer, you never refuse to take any chances when it has to do with your health or the health of loved.

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Stages of mesothelioma

Treatment of mesothelioma is tailored uniquely for each patient. Often the scene of the malignant mesothelioma at diagnosis dictates treatment options. Directed by a particular disease help also to the medical team in planning not only treatment but also in estimating prognosis as well as in the identification of existing clinical trials that the patient may be eligible. Three staging systems are currently used for pleural mesothelioma. None is used for Peritoneal Mesothelioma.

Knowledge of how to develop a particular cancer is relevant for the staging process. Some staging systems cover only specific cancer while others can be used to cover a variety of types. Some common elements are found in most development scene of systems, namely, location of the primary tumor, the tumor size the number of tumor, lymph node, type of histology, grade of the tumor and the presence of metastases.

To accurately determine the stage of cancer, doctors are usually based on a variety of techniques. It is physical examinations, including roentgenograms, CT scans, MRI, imaging techniques and analysis of PET. Review of blood, urine, serum and tissues of the patient biopsy can also provide useful clues. Tumor markers can also be used. Pathology reports are very useful to provide information on the exact size of the tumor, extension of the tumor in the neighbouring structures and histology of the tumor and the category. Surgical reports also provide assistance to the staging.

The most frequent, cancer staging system is used for mesothelioma is the TNM (primary tumor, regional lymph nodes, distant metastases). Stage I is affected when mesothelioma involves only pleura, ipsilateral lung, pericardium ipsilateral and ipsilateral diaphragm. Lymph nodes are not affected. Phase II is assigned when Mesothelioma has already involved the Hilaire ganglia near the side contralateral. The lung, pericardium, or diaphragm on the side contralateral may also be involved. Stage III is assigned when the Mesothelioma has spread to involve the chest wall, soft tissue, ribs, heart, esophagus, or other organs in the chest cavity in the side ipsilateral. Lymph nodes may or may spread to the lymph nodes on the same side as the primary tumor. Stage IV is assigned to the disease has either already spread to the lymph nodes in the chest on the side contralateral to the primary tumor, extended to the contralateral pleura, or extended to the organs in the abdominal cavity or neck. Presence of distant metastases is considered stage IV.

Butchart is the oldest system of gathering for cancers. It is also the most commonly used system of gathering for all types of cancer. The extent of the primary tumor, the mass is the basis of this system. Stage I is affected when mesothelioma is located in any pleura, or on the ipsilateral diaphragm. Phase II is assigned when the Mesothelioma has spread to the chest wall, oesophagus, heart, or pleura on both sides. The lymph nodes in the chest may also be affected. Stage III is assigned when the Mesothelioma has invaded the diaphragm and reached the peritoneum. Lymph nodes outside of the chest may also be involved. Stage IV is assigned when there is evidence of distant metastases.

The Brigham system is the latest system to develop. Resectability and lymph nodes of participation is the basis of this system. Stage I is affected when mesothelioma is resectable always, with any of the lymph nodes. Phase II is assigned when mesothelioma is resectable but are involved in the lymph nodes. Stage III is allocated when mesothelioma is inoperable, extended to the neighbours of the structures of the chest and may or may not have extrathoracic lymph nodes. Stage IV is assigned when there are distant metastases.

Information gleaned from these systems of rest shall be disclosed to the patient. Patients reserve the right to know the exact state of their disease and all parties involved will benefit greatly when this disclosure is made.

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